منابع مشابه
Microbial K+ Channels
A survey of the currently available genomes shows that K channels are found in most free-living bacteria, archaea, and protists, indicating early evolution before the divergences of the three major domains of life. Though vertically descended from the primordial K channels, more recent lateral transfers of K channel genes must also have occurred. Variations in the motifs of transmembrane or cyt...
متن کامل-activated K Channels
BK channels modulate neurotransmitter release due to their activation by voltage and Ca 2 . Intracellular Mg 2 also modulates BK channels in multiple ways with opposite effects on channel function. Previous single-channel studies have shown that Mg 2 blocks the pore of BK channels in a voltage-dependent manner. We have confirmed this result by studying macroscopic currents of the mslo1 channel....
متن کاملSingle Streptomyces lividans K+ Channels
Basic electrophysiological properties of the KcsA K(+) channel were examined in planar lipid bilayer membranes. The channel displays open-state rectification and weakly voltage-dependent gating. Tetraethylammonium blocking affinity depends on the side of the bilayer to which the blocker is added. Addition of Na(+) to the trans chamber causes block of open-channel current, while addition to the ...
متن کاملLysophosphatidic acid-operated K+ channels.
Lysophosphatidic acid (LPA) is an abundant cellular lipid with a myriad of biological effects. It plays an important role in both inter- and intracellular signaling. Activation of the LPA1-3 G-protein-coupled receptors explains many of the extracellular effects of LPA, including cell growth, differentiation, survival, and motility. However, LPA also acts intracellularly, activating the nuclear ...
متن کاملMolecular diversity of K+ channels.
K+ channel principal subunits are by far the largest and most diverse of the ion channels. This diversity originates partly from the large number of genes coding for K+ channel principal subunits, but also from other processes such as alternative splicing, generating multiple mRNA transcripts from a single gene, heteromeric assembly of different principal subunits, as well as possible RNA editi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2005
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.200509261